The following organisations use ESCO to conduct statistical research and big data analysis of the labour market:
- Arbeidsmarktinzicht, the Netherlands
- Australia's National Science Organisation (CSIRO), Australia
- Burning Glass Technologies, USA
- CEDEFOP, Greece
- CRISP, Italy
- ETH, Switzerland
- European Lung Foundation, Belgium
- Intelligence Group, the Netherlands
- Inter-American Development Bank, USA
- National Training and Employment service, Chile
- NESTA, UK
- University of Cambridge, UK
- University of Harvard, USA
- University of Information Technology and Management of Rzeszow, Poland
- West University of Timisoara, Romania
- Wollybi,Italy