The following organisations use ESCO to provide career guidance services:
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- Askfood project, EU countries
- Australia's National Science Organisation (CSIRO), Australia
- BlockAdemiC project, Greece
- Boost.rs, France
- Caisse de Depots, France
- Certif-ID, Germany
- Cities of Learning by Badgecraft, EU countries
- Continuum, Chile
- Credential engine, USA
- Develop project, EU countries
- Dassault systems, France
- eHRgo, France
- eLene4Life project, EU countries
- Estonian Qualification Authority (OSKA) , Estonia
- EU-learn, the European Commission
- Europass the European Commission
- Europe Interoperable Academy EU countries
- European Broadcasting Union (EBU), Switzerland
- Fondazione Bruno Kessler, Italy
- Headai, Finland
- House of Skills, the Netherlands
- Inforelea, Italy
- Jose Neves Foundation, Portugal
- Knowledge Innovation Center, EU countries
- Nastspec, UK
- Nxus, the Netherlands
- ODEM, Switzerland
- Open Badge Factory, Finland
- Orange Cat, the Netherlands
- Peers Solutions, Germany
- Relink, Chile
- Riga Stradiņš University, Latvia
- Seven, France
- SkillLab, the Netherlands
- Skills beyond the seas project by Sea Teach, Spain
- Skills development Scotland, UK
- Skills Guide by Accenture, the Netherlands
- SkillsBoard, France
- Skillscharge by EIT – Inno-energy, EU countries
- Skillsmatch project, EU countries
- TESEO project, EU countries
- The Adecco Group, global
- The creative FLIP project, EU countries
- Timber Construction Europe, EU countries
- University of Florence, Italy
- University of Tampere, Finland
- VET Voices, EU countries
- Worldskills, global
- Xtoit,France